MECHANISM OF SPONTANEOUS, CONCENTRATION-DEPENDENT PHOSPHOLIPID TRANSFER BETWEEN BILAYERS

被引：75
作者：
JONES, JD [1 ]
THOMPSON, TE [1 ]
机构：
[1] UNIV VIRGINIA,DEPT BIOCHEM,CHARLOTTESVILLE,VA 22908
来源：
BIOCHEMISTRY | 1990年 / 29卷 / 06期
关键词：
D O I：
10.1021/bi00458a034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have previously demonstrated that spontaneous phospholipid transfer between bilayer vesicles at higher vesicle concentrations is characterized not only by a first-order desorption rate but also by a second-order process dependent on vesicle concentration (Jones & Thompson, 1989b). We have extended our studies to examine the mechanism of this second-order process by investigating transfer as a function of lipid type, temperature, aqueous medium composition, and vesicle size. The results suggest a mechanism of concentration-dependent transfer in which the rate of lipid monomer desorption from vesicle bilayers is enhanced in transient vesicle-vesicle complexes. © 1990, American Chemical Society. All rights reserved.
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页码：1593 / 1600
页数：8
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