INVIVO 24-HYDROXYLATION OF 25-HYDROXYVITAMIN-D3 IN ENTEROCOLECTOMIZED RATS

被引：6

作者：

KUMAR, R

SILVA, P

EPSTEIN, FH

机构：

[1] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DEPT MED,BOSTON,MA 02215

[2] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,THORNDIKE LAB,BOSTON,MA 02215

来源：

ENDOCRINOLOGY | 1979年 / 104卷 / 06期

关键词：

D O I：

10.1210/endo-104-6-1794

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To determine if the renal 25-hydroxyvitamin D3 24-hydroxylase is active in addition to the intestinal 25-hydroxyvitamin D3 24-hydroxylase in vivo in the rat, radiolabeled 25-hydroxyvitamin D3 was administered to noftnocalcemic, vitamin D-replete, enterocolectomized rats. Substantial amounts of 24, 25-dihydroxyvitamin D3 were detected and the identity of the isolated plasma 24, 25-dihydroxyvitamin D3 region in these animals was confirmed by coelution on high pressure liquid chromatography and periodate cleavage. This suggests that both intestinal and renal 25-hydroxyvitamin D3 24-hydroxylases are active in vivo in the rat. © 1979 by The Endocrine Society.

引用

页码：1794 / 1796

页数：3