INVIVO 24-HYDROXYLATION OF 25-HYDROXYVITAMIN-D3 IN ENTEROCOLECTOMIZED RATS

被引：6
作者：
KUMAR, R
SILVA, P
EPSTEIN, FH
机构：
[1] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DEPT MED,BOSTON,MA 02215
[2] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,THORNDIKE LAB,BOSTON,MA 02215
来源：
ENDOCRINOLOGY | 1979年 / 104卷 / 06期
关键词：
D O I：
10.1210/endo-104-6-1794
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To determine if the renal 25-hydroxyvitamin D3 24-hydroxylase is active in addition to the intestinal 25-hydroxyvitamin D3 24-hydroxylase in vivo in the rat, radiolabeled 25-hydroxyvitamin D3 was administered to noftnocalcemic, vitamin D-replete, enterocolectomized rats. Substantial amounts of 24, 25-dihydroxyvitamin D3 were detected and the identity of the isolated plasma 24, 25-dihydroxyvitamin D3 region in these animals was confirmed by coelution on high pressure liquid chromatography and periodate cleavage. This suggests that both intestinal and renal 25-hydroxyvitamin D3 24-hydroxylases are active in vivo in the rat. © 1979 by The Endocrine Society.
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页码：1794 / 1796
页数：3
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