STRUCTURE OF MALHAMENSILIPIN-A, AN INHIBITOR OF PROTEIN-TYROSINE KINASE, FROM THE CULTURED CHRYSOPHYTE POTERIOOCHROMONAS-MALHAMENSIS

被引：49

作者：

CHEN, JL

PROTEAU, PJ

ROBERTS, MA

GERWICK, WH

SLATE, DL

LEE, RH

机构：

[1] OREGON STATE UNIV,COLL PHARM,CORVALLIS,OR 97331

[2] SYNTEX INC,RES,INST BIOCHEM & CELL BIOL,PALO ALTO,CA 94304

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 04期

关键词：

D O I：

10.1021/np50106a015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new chlorosulfolipid, malhamensilipin A [1] was isolated from the cultured chrysophyte Poterioochromonas malhamensis. Malhamensilipin A was demonstrated to be a modest inhibitor of pp60(v-src) protein tyrosine kinase. The structure was determined by derailed spectral analysis to be a novel C-24 hexachloro lipid containing a vinyl sulfate ester (2,11,12,13,15,16-hexachloro-14-hydroxy-n-tetracos-1E-enol-1-sulfate).

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页码：524 / 527

页数：4

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