AMANTADINE-RESISTANT INFLUENZA-A IN A NURSING FACILITY

被引：55

作者：

DEGELAU, J ^{[1
]}

SOMANI, SK ^{[1
]}

COOPER, SL ^{[1
]}

GUAY, DRP ^{[1
]}

CROSSLEY, KB ^{[1
]}

机构：

[1] ST PAUL RAMSEY MED CTR,CLIN PHARM SECT,ST PAUL,MN 55101

来源：

ARCHIVES OF INTERNAL MEDICINE | 1992年 / 152卷 / 02期

关键词：

D O I：

10.1001/archinte.152.2.390

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rapid index case treatment and amantadine prophylaxis were implemented in two nursing homes exposed to influenza A. Facility A had no isolation of cases, and 18 of 22 cases occurred after amantadine hydrochloride therapy was initiated. Three patients exhibited amantadine-resistant virus. Facility B had day 1 isolation of the index case. A facility-wide outbreak did not occur. The experience of these facilities suggests that concurrent amantadine treatment and prophylaxis without adequate case isolation may promote further influenza A infection in a nursing facility.

引用

页码：390 / 392

页数：3

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