IMAGING THE DOPAMINE UPTAKE SITE WITH EXVIVO [F-18] GBR-13119 BINDING AUTORADIOGRAPHY IN RAT-BRAIN

被引：17
作者：
CILIAX, BJ
KILBOURN, MR
HAKA, MS
PENNEY, JB
机构：
[1] UNIV MICHIGAN, DEPT NEUROL, 1103 E HURON ST, ANN ARBOR, MI 48104 USA
[2] UNIV MICHIGAN, DIV NUCL MED, ANN ARBOR, MI 48104 USA
来源：
JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 02期
关键词：
Dopamine uptake; Positron emission tomography scanning; [!sup]18[!/sup]F]GBR 13119–6‐Hydroxydopamine lesions;
D O I：
10.1111/j.1471-4159.1990.tb04178.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We studied the binding of [18F]GBR 13119 {1‐[[(4‐[18F]fluorophenyl) (phenyl)methoxy]ethyl]‐4‐(3‐phenylpropyl)piperazine} to rat brain with autoradiography after intravenous injection. The rank order of binding was dorsal striatum > nucleus accumbens = olfactory tubercle > sub‐stantia nigra = ventral tegmental area > other areas. Binding was blocked by prior injection of dopamine uptake blockers but not by injection of dopamine receptor antagonists or drugs that bind to the dialkylpiperazine site. Unilateral 6‐hydroxy dopamine lesions of dopamine neurons caused a marked decrease in striatal and nigral binding on the side of the lesion. We conclude that intravenous injection of [18F]GBR 13119 provides a useful marker of presynaptic dopamine uptake sites. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：619 / 623
页数：5
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