DOMINANT NEGATIVE REGULATION OF THE MOUSE ALPHA-FETOPROTEIN GENE IN ADULT LIVER

被引：127
作者：
VACHER, J
TILGHMAN, SM
机构：
[1] Howard Hughes Medical Institute, Department of Biology, Princeton University, Princeton
来源：
SCIENCE | 1990年 / 250卷 / 4988期
关键词：
D O I：
10.1126/science.1702902
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Transcription of the mouse α-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation she of the α-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.
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页码：1732 / 1735
页数：4
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