ALPHA-NAPHTHOFLAVONE - AN INHIBITOR OF HYDROCARBON CYTOTOXICITY AND MICROSOMAL HYDROXYLASE

被引：208
作者：
DIAMOND, L
GELBOIN, HV
机构：
[1] Wistar Institute of Anatomy and Biology, Philadelphia
[2] Chemistry Branch, National Cancer Institute, Bethesda
来源：
SCIENCE | 1969年 / 166卷 / 3908期
关键词：
D O I：
10.1126/science.166.3908.1023
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster embryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. Alpha-naphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells and in liver microsomes from rats previously treated with polycyclic aromatic hydrocarbons, but not in microsomes from control rats.
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页码：1023 / &
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