SOLID-STATE NMR STRUCTURAL STUDIES OF PEPTIDES AND PROTEINS IN MEMBRANES

被引：182

作者：

CROSS, TA ^{[1
]}

OPELLA, SJ ^{[1
]}

机构：

[1] UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(94)90220-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Solid-state NMR spectroscopy is emerging as a new approach in the structural investigations of peptides and proteins in membrane bilayers. Orientational parameters obtained from samples aligned on glass plates have been used to determine their secondary structures and orientations in the bilayer. They have also been used in the determination of the high resolution structure of gramicidin. Additional structural information, distance measurements between pairs of different nuclei and between pairs of like nuclei has been obtained on peptides in bilayers using magic angle spinning methods.

引用

页码：574 / 581

页数：8

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