VASCULAR AND CALCEMIC EFFECTS OF PLASMA OF SPONTANEOUSLY HYPERTENSIVE RATS

被引：13

作者：

LEWANCZUK, RZ ^{[1
]}

PANG, PKT ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT MED,EDMONTON T6G 2H7,ALBERTA,CANADA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 08期

关键词：

Calcium; Circulating hypertensive factor; Parathyroid hormone; Spontaneously hypertensive rat;

D O I：

10.1093/ajh/3.8.189

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Circulating substances that increase intracellular calcium, and other circulating substances that increase blood pressure, have been described in hypertensive animals and humans. In this study, we report the existence of a factor of the plasma of spontaneously hypertensive rats that does both. These effects were dose-dependent, and the time course for such effects was correlated with the time course for potentiation of pressor agents by the plasma. In addition, the plasma of spontaneously hypertensive rats was found to inhibit the depressor effects of parathyroid hormone. Our results confirm the presence of a circulating hypertensive factor in the plasma of spontaneously hypertensive rats, which may act by increasing calcium uptake in vascular smooth muscle. These findings may also help explain the secondary increase in parathyroid hormone noted in some forms of human and experimental hypertension. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：S189 / S194

页数：6

共 40 条

[1]

Resnick L.M., Calcium and hypertension: the emerging connection, Ann Intern Med, 103, pp. 944-946, (1985)

[2]

Resnick L.M., Muller F.B., Laragh J.H., Calcium-regulating hormones in essential hypertension, Ann Intern Med, 105, pp. 649-654, (1986)

[3]

Grobbee D.E., Hacking W.H.L., Birkenhager J.C., Et al., Raised plasma intact parathyroid hormone concentrations in young people with mildly raised blood pressure, Br Med J, 296, pp. 814-816, (1988)

[4]

Hvarfner A., Bergstrom R., Morlin C., Et al., Relationship between calcium metabolic indices and blood pressure in patients with essential hypertension as compared with a healthy population, J Hypertens, 5, pp. 451-456, (1987)

[5]

Hellstrom J., Birke G., Edvall C.A., Hypertension in hyperparathyroidism, Br J Urol, 30, pp. 13-24, (1958)

[6]

Rosenthal F.D., Roy S., Hypertension and hyperparathyroidism, Br Med J, 4, pp. 396-397, (1972)

[7]

Christenson T., Hellstrom K., Wangle B., Blood pressure in subjects with hypercalcemia and primary hyperparathyroidism detected in health screening program, Eur J Clin Invest, 7, pp. 109-113, (1977)

[8]

Schleiffer R., Berthelot A., Pernot F., Et al., Parathyroids, thyroid and development of hypertension in SHR, Jpn Circ J, 45, pp. 1272-1279, (1981)

[9]

Schleiffer R., Pernot F., Gairard A., Parathyroidectomy, cardiovascular reactivity and calcium distribution in aorta and heart of spontaneously hypertensive rats, Clin Sci, 71, pp. 505-511, (1986)

[10]

Mann J.F.E., Wiecek A., Bommer J., Et al., Effects of parathyroidectomy on blood pressure in spontaneously hypertensive rats, Nephron, 45, pp. 46-52, (1987)

← 1 2 3 4 →