INFLUENCE OF VARIOUS 2-SUBSTITUTED AND 2'-SUBSTITUTED POLYADENYLIC ACIDS ON MURINE LEUKEMIA-VIRUS REVERSE-TRANSCRIPTASE

被引：22

作者：

DECLERCQ, E

FUKUI, T

KAKIUCHI, N

IKEHARA, M

HATTORI, M

PFLEIDERER, W

机构：

[1] OSAKA UNIV, FAC PHARMACEUT SCI, SUITA, OSAKA 565, JAPAN

[2] UNIV CONSTANCE, FACHBEREICH CHEM, D-7750 CONSTANCE, FED REP GER

来源：

CANCER LETTERS | 1979年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0304-3835(79)80073-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several newly synthesized polyadenylic acid [(A)n]analogues, including poly(2-methyladenylic acid) [(m2A)n], poly(2-ethyladenylic acid) [(e2A)n], poly(2-isopropyladenylic acid) [(i-pro2A)n], poly(2-methylthioadenylic acid) [(ms2A)n], poly(2-ethylthioadenylic acid) [(es2A)n], poly(2′-fluoro-2′-deoxyadenylic acid) [(dAfl)n] and poly(2′-azido-2′-deoxyadenylic acid) [(dAz)n] have been evaluated for their effects on the RNA-directed DNA polymerase (reverse transcriptase) activity of Moloney murine leukemia virus; (m2A)n and (e2A)n did not markedly affect reverse transcriptase activity, (dAfl)n served as an efficient template for the reverse transcriptase reaction, and (i-pro2A)n, (ms2A)n, (es2A)n and (dAz)n strongly inhibited reverse transcriptase activity. (dAfl)n also served as an efficient template (Km : 0.025 μM) for the reverse transcriptase of avian myeloblastosis virus. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

引用

页码：27 / 37

页数：11

共 23 条

[1]

ARYA SK, 1976, MOL PHARMACOL, V12, P844

[2]

ARYA SK, 1975, MOL PHARMACOL, V11, P501

[3]

ARYA SK, 1976, MOL PHARMACOL, V12, P234

[4]

ARYA SK, 1975, MOL PHARMACOL, V11, P421