ACTION OF LIGHT ON FROG PIGMENT-CELLS IN CULTURE

被引：138

作者：

DANIOLOS, A ^{[1
]}

LERNER, AB ^{[1
]}

LERNER, MR ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,MOLEC NEUROBIOL SECT,NEW HAVEN,CT 06510

来源：

PIGMENT CELL RESEARCH | 1990年 / 3卷 / 01期

关键词：

cAMP; Melanophores; Photoresponse; Rhodopsin;

D O I：

10.1111/j.1600-0749.1990.tb00260.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Solar radiation induces numerous biologic effects in skin but the mechanism underlying these responses is poorly understood. To study the etiology of these phenomena, we investigated the effect of light on cultured Xenopus laevis melanophores. Visible light stimulated a marked increase in intracellular cAMP levels within the first minute of irradiation. This light‐induced elevation in cAMP was blocked by melatonin and was not seen in fibroblasts irradiated in a similar manner. These data show that the photoresponse of pigment cells from amphibian skin can be mediated by a cAMP‐dependent mechanism and suggest that a unique member of the rhodopsin family is involved in this process. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：38 / 43

页数：6

共 41 条

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