REGULATION OF TRANSLATION AND CELL-GROWTH BY EIF-4E

被引：112
作者：
SONENBERG, N [1 ]
机构：
[1] MCGILL UNIV, MCGILL CANC CTR, MONTREAL H3G 1Y6, PQ, CANADA
来源：
BIOCHIMIE | 1994年 / 76卷 / 09期
基金：
英国医学研究理事会;
关键词：
TRANSLATION; EIF-4E; PROTEIN SYNTHESIS; MESSENGER-RNA;
D O I：
10.1016/0300-9084(94)90185-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review discusses the regulation of a key controlling step in the initiation of protein synthesis, the binding of mRNA to ribosomes. Particular focus is given to the phosphorylation of the cap-binding factor, eIF-4E, and the role of this factor in the regulation of cell growth.
引用
收藏
页码：839 / 846
页数：8
相关论文
共 85 条
[21]   PHOSPHORYLATION OF EUKARYOTIC TRANSLATION INITIATION-FACTOR 4E IS INCREASED IN SRC-TRANSFORMED CELL-LINES [J].
FREDERICKSON, RM ;
MONTINE, KS ;
SONENBERG, N .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (05) :2896-2900
[22]   PHOSPHORYLATION OF TRANSLATION INITIATION-FACTOR EIF-4E IS INDUCED IN A RAS-DEPENDENT MANNER DURING NERVE GROWTH FACTOR-MEDIATED PC12 CELL-DIFFERENTIATION [J].
FREDERICKSON, RM ;
MUSHYNSKI, WE ;
SONENBERG, N .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (03) :1239-1247
[23]  
FREDERICKSON RM, 1993, TRANSLATIONAL REGULA, V2, P143
[24]  
GALLIE DR, 1994, J BIOL CHEM, V269, P7174
[25]  
GRIFO JA, 1983, J BIOL CHEM, V258, P5804
[26]  
HERSHEY JWB, 1989, J BIOL CHEM, V264, P20823
[27]   TRANSLATIONAL CONTROL IN MAMMALIAN-CELLS [J].
HERSHEY, JWB .
ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :717-755
[28]   FUNCTION OF A HUMAN CYCLIN GENE AS AN ONCOGENE [J].
HINDS, PW ;
DOWDY, SF ;
EATON, EN ;
ARNOLD, A ;
WEINBERG, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) :709-713
[29]  
HIREMATH LS, 1985, J BIOL CHEM, V260, P7843
[30]   ADENOVIRUS INHIBITION OF CELLULAR PROTEIN-SYNTHESIS INVOLVES INACTIVATION OF CAP-BINDING PROTEIN [J].
HUANG, J ;
SCHNEIDER, RJ .
CELL, 1991, 65 (02) :271-280
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