SOLID-STATE NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY - THEORY AND PHARMACEUTICAL APPLICATIONS

被引：80
作者：
BUGAY, DE
机构：
[1] Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903-0191, 1 Squibb Drive
来源：
PHARMACEUTICAL RESEARCH | 1993年 / 10卷 / 03期
关键词：
SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; CROSS-POLARIZATION MAGIC-ANGLE SPINNING (CP/MAS); THEORY AND PHARMACEUTICAL APPLICATIONS;
D O I：
10.1023/A:1018967717781
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The theory of solid-state nuclear magnetic resonance (NMR) spectroscopy is reviewed, with specific discussions of magnetic interactions in the solid state. Each magnetic interaction (Zeeman, dipole-dipole, chemical-shift, spin-spin, and quadrupolar) is addressed and manifestations of these interactions in the solid state NMR spectrum are explained. The techniques of high-power decoupling, magic-angle spinning, and cross-polarization, used to acquire highly resolved solid-state NMR spectra, are also illustrated. Application of solid-state NMR to pharmaceutical problem solving and methods development is then briefly reviewed.
引用
收藏
页码：317 / 327
页数：11
相关论文
共 50 条
12345