SOLID-STATE NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY - THEORY AND PHARMACEUTICAL APPLICATIONS

被引：80

作者：

BUGAY, DE

机构：

[1] Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903-0191, 1 Squibb Drive

来源：

PHARMACEUTICAL RESEARCH | 1993年 / 10卷 / 03期

关键词：

SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; CROSS-POLARIZATION MAGIC-ANGLE SPINNING (CP/MAS); THEORY AND PHARMACEUTICAL APPLICATIONS;

D O I：

10.1023/A:1018967717781

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The theory of solid-state nuclear magnetic resonance (NMR) spectroscopy is reviewed, with specific discussions of magnetic interactions in the solid state. Each magnetic interaction (Zeeman, dipole-dipole, chemical-shift, spin-spin, and quadrupolar) is addressed and manifestations of these interactions in the solid state NMR spectrum are explained. The techniques of high-power decoupling, magic-angle spinning, and cross-polarization, used to acquire highly resolved solid-state NMR spectra, are also illustrated. Application of solid-state NMR to pharmaceutical problem solving and methods development is then briefly reviewed.

引用

页码：317 / 327

页数：11

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