Differential expression of inducible nitric oxide synthase mRNA in human brain tumours

被引：13
作者：
Ellie, E
Loiseau, H
Lafond, F
Arsaut, J
DemotesMainard, J
机构：
[1] INSERM,U394 NEUROBIOL INTEGRAT,F-33077 BORDEAUX,FRANCE
[2] UNIV HOSP BORDEAUX,DEPT NEUROSURG,BORDEAUX,FRANCE
来源：
NEUROREPORT | 1995年 / 7卷 / 01期
关键词：
brain neoplasms; glioblastoma; meningioma; nitric oxide; cytokine; nitric oxide synthase;
D O I：
10.1097/00001756-199512290-00070
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
MESSENGER RNA encoding the inducible form of human nitric oxide synthase (iNOS) was quantified by reverse transcription and polymerase chain reaction (RT-PCR) in tissue samples from glioblastomas and meningiomas. iNOS mRNA expression was considerably higher in the glioblastoma than in the meningioma specimens (mean +/- s.e.m., 41.18 +/- 11.5, n = 25, vs 5.31 +/- 0.98, n = 21; p < 0.0001). Moreover, iNOS expression appeared as a polymorphic character among glioblastomas, as individual tumours expressed either high (n = 6), intermediate (n = 10) or low (n = 9) levels of iNOS mRNA.
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收藏
页码：294 / 296
页数：3
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