GROWTH-FACTORS AND EXTRACELLULAR SIGNAL-REGULATED KINASES (MITOGEN-ACTIVATED PROTEIN-KINASE) IN THE RAT PINEAL-GLAND

被引：6

作者：

KIYAMA, H

WANAKA, A

KATO, H

MAENO, H

MATSUMOTO, K

SUN, GG

SHIOSAKA, S

TOHYAMA, M

机构：

[1] OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV,SCH MED,BIOMED RES CTR,DEPT NEUROANAT,SUITA,OSAKA 565,JAPAN

来源：

NEUROENDOCRINOLOGY | 1994年 / 59卷 / 02期

关键词：

BASIC FIBROBLAST GROWTH FACTOR; NERVE GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; NERVE GROWTH FACTOR RECEPTOR; EXTRACELLULAR SIGNAL-REGULATED KINASE; PINEAL GLAND; MITOGEN-ACTIVATED PROTEIN KINASE;

D O I：

10.1159/000126652

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study revealed that the pineal gland expressed basic fibroblast growth factor (bFGF) and FGF-receptor 1 (FGFR1/flg), suggesting that bFGF in the pineal gland acts in an autocrine or paracrine manner, which is mediated by FGFR1/flg. The present study also examined gene expression of the extracellular signal-regulated kinase (ERK) family (ERK1-3) which may be intracellular signal mediators of growth factors. ERK1 [mitogen-activated protein kinase (MAP-kinase)] was strongly expressed throughout the pineal gland, while expression of ERK2 and ERK3 was not found. These findings suggest the presence of a signal pathway from bFGF to ERK1 via FGFR1/flg in the pineal gland.

引用

页码：152 / 155

页数：4

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