SPONGIFORM ALTERATIONS IN BRAIN BIOPSIES OF PRESENILE-DEMENTIA

被引：78

作者：

FLAMENTDURAND, J

COUCK, AM

机构：

[1] Department of Pathology and Electron Microscopy, Université Libre de Bruxelles, Brussels

来源：

ACTA NEUROPATHOLOGICA | 1979年 / 46卷 / 1-2期

关键词：

Alzheimer's disease; Creutzfeldt-Jakob disease; Hirano bodies; Spongiform degeneration;

D O I：

10.1007/BF00684819

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Spongiform lesions were observed in close association with typical presenile alterations in three of six frontal lobe biopsies taken in presenile demented patients without any familial relationship. These findings are discussed in relation with recent investigations indicating the production of spongiform lesions after inoculation of nervous tissue from an Alzheimer patient to animals and the effects of saline extract of such material on cultured nerve cells. © 1979 Springer-Verlag.

引用

页码：159 / 162

页数：4

共 13 条

[1]

Capon A, 1976, Rev Electroencephalogr Neurophysiol Clin, V6, P130, DOI 10.1016/S0370-4475(76)80074-3

[2] PAIRED HELICAL FILAMENTS OF ALZHEIMER TYPE IN CULTURED NEURONS [J].