ABNORMAL FEAR RESPONSE AND AGGRESSIVE-BEHAVIOR IN MUTANT MICE DEFICIENT FOR ALPHA-CALCIUM-CALMODULIN KINASE-II

被引：221

作者：

CHEN, C

RAINNIE, DG

GREENE, RW

TONEGAWA, S

机构：

[1] MIT, CTR CANC RES, CAMBRIDGE, MA 02139 USA

[2] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

[3] HARVARD UNIV, SCH MED, DEPT PSYCHIAT, BROCKTON, MA 02401 USA

[4] VET ADM MED CTR, BROCKTON, MA 02401 USA

来源：

SCIENCE | 1994年 / 266卷 / 5183期

关键词：

D O I：

10.1126/science.7939668

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mice deficient for the gene encoding alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with a specific molecular lesion. The heterozygous mouse exhibited a well-circumscribed syndrome of behavioral abnormalities, consisting primarily of a decreased fear response and an increase in defensive aggression, in the absence of any measured cognitive deficits. Unlike the heterozygote, the homozygote displayed abnormal behavior in all paradigms tested. At the cellular level, both extracellular and whole-cell patch clamp recordings indicated that serotonin release in putative serotonergic neurons of the dorsal raphe was reduced. Thus, alpha-CaMKII knockout mice, in particular the heterozygote, may provide a model for studying the molecular and cellular basis underlying emotional disorders involving fear and aggression.

引用

页码：291 / 294

页数：4

共 36 条

[1] PKC-GAMMA MUTANT MICE EXHIBIT MILD DEFICITS IN SPATIAL AND CONTEXTUAL LEARNING [J].