NOVEL FUROSTANOL GLYCOSIDES FROM ALLIUM MACROSTEMON

被引：48

作者：

PENG, JP

YAO, XS

KOBAYASHI, H

MA, CY

机构：

[1] ACAD MIL MED SCI, INST RADIAT MED, DEPT APPL MED RES, BEIJING 100850, PEOPLES R CHINA

[2] UNIV TOKYO, INST APPL MICROBIOL, TOKYO 113, JAPAN

来源：

PLANTA MEDICA | 1995年 / 61卷 / 01期

关键词：

ALLIUM MACROSTEMON BUNGE; LILIACEAE; FUROSTANOL SAPONIN; MACROSTEMONOSIDE G; MACROSTEMONOSIDE H; MACROSTEMONOSIDE I; INHIBITION OF ADP-INDUCED HUMAN PLATELET AGGREGATION;

D O I：

10.1055/s-2006-958000

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Further studies by means of preparative HPLC led to the isolation of two new furostanol saponins, macrostemonosides G (1) and I (3), along with an artifact, macrostemonoside H (2) from the bulbs of Allium macrostemon Bunge. On the basis of chemical evidence and spectral analyses (H-1-, C-13-NMR, H-1-H-1 COSY, H-1-C-13 COSY, HMBC, and FAB-MS), the structure of 1. was established as 26-O-beta-D-glucopyranosyl-22-hydroxy-5 beta-furost-25(27)-ene-3 beta,12 beta,26-triol 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-galactopyranoside and 2 as the 22-methoxy derivative of 1; 3 was deduced to be 26-O-beta-D-glucopyranosyl-22-hydroxy-5 beta-furost-25(27)-ene-12-one-3 beta,26-diol 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-galactopyranoside. Preliminary pharmacological tests showed that macrostemonoside G (1) could inhibit ADP-induced human platelet aggregation in vitro (IC50 = 0.871 mM).

引用

页码：58 / 61

页数：4

共 11 条

[1] C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].