THALIDOMIDE TERATOGENESIS - EVIDENCE FOR A TOXIC ARENE OXIDE METABOLITE

被引:130
作者
GORDON, GB
SPIELBERG, SP
BLAKE, DA
BALASUBRAMANIAN, V
机构
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT GYNECOL & OBSTET,DIV CLIN PHARMACOL,BALTIMORE,MD 21205
来源
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1981年 / 78卷 / 04期
关键词
D O I
10.1073/pnas.78.4.2545
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:2545 / 2548
页数:4
相关论文
共 24 条
[1]   THALIDOMIDE SYNDROME IN MONKEYS [J].
DELAHUNT, CS ;
LASSEN, LJ .
SCIENCE, 1964, 146 (364) :1300-&
[2]   TERATOGENIC ACTIVITY OF THALIDOMIDE AND RELATED COMPOUNDS [J].
FABRO, S ;
SCHUMACHER, H ;
SMITH, RL ;
WILLIAMS, RT .
LIFE SCIENCES, 1964, 3 (09) :987-992
[3]   TERATOGENIC EFFECTS OF THALIDOMIDE IN RABBITS RATS HAMSTERS AND MICE [J].
FRATTA, ID ;
SIGG, EB ;
MAIORANA, K .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1965, 7 (02) :268-+
[4]   CULTURED MOUSE EMBRYOS METABOLIZE BENZO[A]PYRENE DURING EARLY GESTATION - GENETIC-DIFFERENCES DETECTABLE BY SISTER CHROMATID EXCHANGE [J].
GALLOWAY, SM ;
PERRY, PE ;
MENESES, J ;
NEBERT, DW ;
PEDERSEN, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (06) :3524-3528
[5]   ARENE OXIDES - NEW ASPECT OF DRUG-METABOLISM [J].
JERINA, DM ;
DALY, JW .
SCIENCE, 1974, 185 (4151) :573-582
[6]  
JONSSON NA, 1972, ACTA PHARM SUEC, V9, P521
[7]   THALIDOMIDE ANALOGUES [J].
KOCH, H ;
KOTLAN, J .
MONATSHEFTE FUR CHEMIE UND VERWANDTE TEILE ANDERER WISSENSCHAFTEN, 1966, 97 (06) :1648-&
[8]  
LENZ W, 1962, LANCET, V1, P45
[9]  
LU AYH, 1975, J BIOL CHEM, V250, P8283
[10]  
MARTZ F, 1977, J PHARMACOL EXP THER, V203, P231