DETERMINATION OF THE ENANTIOMER OF A CHOLESTEROL-LOWERING DRUG BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY

被引：32
作者：
NOROSKI, JE
MAYO, DJ
MORAN, M
机构：
[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, New Brunswick, NJ 08903-0191
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 01期
关键词：
CHIRAL; CZE; CYCLODEXTRIN; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; CD-MEKC; MEKC;
D O I：
10.1016/0731-7085(94)00110-N
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The development, optimization and application of a chiral CE (capillary electrophoresis) method for the determination of the enantiomer content of a new cholesterol-lowering drug (EMS-180431-09) is discussed. The chiral CE technique, cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC), was employed with hydroxypropyl beta-cyclodextrin as the chiral selector in the run buffer. The detection limit of the unwanted enantiomer was about 0.06% w/w. The effect of various parameters on the separation, validation data and examples of the application of the chiral CE method are included.
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页码：45 / 52
页数：8
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