REVERSE-TRANSCRIPTASE MUTATIONS IN SEQUENTIAL HIV-1 ISOLATES IN A PATIENT WITH AIDS

被引：17

作者：

GURUSINGHE, AD

LAND, SA

BIRCH, C

MCGAVIN, C

HOOKER, DJ

TACHEDJIAN, G

DOHERTY, R

DEACON, NJ

机构：

[1] MACFARLANE BURNET CTR MED RES,VIRUS INTERACT LAB,FAIRFIELD,VIC 3078,AUSTRALIA

[2] NATL CTR HIV VIROL RES,AIDS MOLEC BIOL LAB,FAIRFIELD,VIC,AUSTRALIA

[3] NATL CTR HIV VIROL RES,ANTIVIRALS RES LAB,FAIRFIELD,VIC,AUSTRALIA

[4] FAIRFIELD HOSP,VICTORIAN STATE HIV ISOLAT LAB,FAIRFIELD,VIC 3078,AUSTRALIA

来源：

JOURNAL OF MEDICAL VIROLOGY | 1995年 / 46卷 / 03期

关键词：

HIV-1; AZT; RESISTANCE; REVERSE TRANSCRIPTASE; MUTATIONS;

D O I：

10.1002/jmv.1890460312

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sequential human immunodeficiency virus type 1 (HIV-1) isolates were obtained over a 29-month period from a person before, during, and after AZT therapy. DNA sequence analysis of polymerase chain-amplified reverse-transcriptase gene showed a gradual accumulation of mutations to peak resistance (IC50 2.13 mu M AZT) in association with mutations at codons 44, 210, and 369, as well as at 41, 67, 70, and 215. Eight months after cessation of AZT therapy, when an HIV-1 isolate from the patient was again sensitive to AZT, these mutations had all returned to the pretherapy sequence. (C) 1995 Wiley-Liss, Inc.

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页码：238 / 243

页数：6

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