CUMULATIVE MEAN CHANGE PROCEDURE - APPLICATION TO A COMPARATIVE TRIAL OF VENLAFAXINE, IMIPRAMINE, AND PLACEBO IN THE TREATMENT OF MAJOR DEPRESSION

被引：5

作者：

ENTSUAH, AR ^{[1
]}

BRADLEY, MM ^{[1
]}

LITTMAN, GS ^{[1
]}

机构：

[1] WYETH AYERST RES,CLIN BIOSTAT,RADNOR,PA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1994年 / 18卷 / 04期

关键词：

CLINICAL TRIALS; CUMULATIVE MEAN CHANGE; REPEATED MEASURES; SUMMARY STATISTICS;

D O I：

10.1016/0278-5846(94)90077-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. A simple summary measure - namely, cumulative mean change (CMC) - is proposed for analyzing incomplete repeated measures in clinical settings. 2. A simple test statistic that uses the correlation between subject responses was derived and applied to a study comparing an investigational antidepressant, venlafaxine, with imipramine and placebo. 3. The global fashion in which CMC captured all data confirmed the efficacy advantage of venlafaxine over the two control agents.

引用

页码：695 / 706

页数：12

共 15 条

[1]

ALVIR JMJ, 1990, PSYCHOPHARMACOL BULL, V26, P203

[2]

AZEN SP, 1989, STAT MED, V8, P17

[3] COMPUTING FOR INCOMPLETE REPEATED MEASURES [J].