THE MOUSE EB MEIOTIC RECOMBINATION HOTSPOT CONTAINS A TISSUE-SPECIFIC TRANSCRIPTIONAL ENHANCER

被引：11

作者：

LING, XB ^{[1
]}

SHENKAR, R ^{[1
]}

SAKAI, D ^{[1
]}

ARNHEIM, N ^{[1
]}

机构：

[1] UNIV SO CALIF,MOLEC BIOL SECT,LOS ANGELES,CA 90089

来源：

IMMUNOGENETICS | 1993年 / 37卷 / 05期

关键词：

D O I：

10.1007/BF00216797

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A meiotic recombination hotspot exists within the second intron of the mouse major histocompatibility complex (MHC) gene, Eb. In the present study, a small fragment from the intron which contains two potential transcriptional regulatory elements was cloned into an expression vector and its effect on transcription was tested. This fragment was found to contain tissue-specific transcriptional enhancer activity. An octamer-like sequence and a B motif may contribute to this enhancer activity. Similar regulatory sequences with the same orientation and distance from one another are found in another mouse MHC recombination hotspot.

引用

页码：331 / 336

页数：6

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