X-LINKAGE AND MANIC-DEPRESSIVE ILLNESS - A REASSESSMENT

被引：0

作者：

BARON, M ^{[1
]}

机构：

[1] NEW YORK STATE PSYCHIAT INST & HOSP,DEPT MED GENET,NEW YORK,NY 10032

来源：

SOCIAL BIOLOGY | 1991年 / 38卷 / 3-4期

关键词：

D O I：

暂无

中图分类号：

C921 [人口统计学];

学科分类号：

摘要：

Genetic-epidemiological data and linkage studies with chromosomal markers are reviewed from the vantage point of X-linked inheritance. The results overall suggest that a gene predisposing to manic depression (bipolar affective illness) localized on the X-chromosome may exist in a subgroup of bipolar cases. However, in light of conflicting findings and methodological uncertainties in studying a disorder with unclear phenotype and complex inheritance, this issue is not yet closed. Additional research, including new linkage data and extension and re-evaluation of published data, is required to further our understanding of this intriguing hypothesis.

引用

页码：179 / 188

页数：10

共 39 条

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BARON, M .

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[2] X-LINKAGE IN BIPOLAR AFFECTIVE-ILLNESS - PERSPECTIVES ON GENETIC-HETEROGENEITY, PEDIGREE ANALYSIS AND THE X-CHROMOSOME MAP [J].

BARON, M ;

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RISCH, N .

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BARON, M ;

HAMBURGER, R ;

SANDKUYL, LA ;

RISCH, N ;

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ENDICOTT, J ;

BELMAKER, RH ;

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ACTA PSYCHIATRICA SCANDINAVICA, 1990, 82 (03) :196-203

[4] GENETIC-LINKAGE BETWEEN X-CHROMOSOME MARKERS AND BIPOLAR AFFECTIVE-ILLNESS [J].

BARON, M ;

RISCH, N ;

HAMBURGER, R ;

MANDEL, B ;

KUSHNER, S ;

NEWMAN, M ;

DRUMER, D ;

BELMAKER, RH .

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[5]

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BARON, M ;

ENDICOTT, J ;

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[7]

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[8]

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[9]

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[10]

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