DOES OVARIAN STIMULATION FOR INVITRO FERTILIZATION INDUCE A HYPERCOAGULABLE STATE

被引：71
作者：
AUNE, B
HOIE, KE
OIAN, P
HOLST, N
OSTERUD, B
机构：
[1] Department of Obstetrics and Gynaecology, Institute of Medical Biology, University of Tromsø, Tromsø
来源：
HUMAN REPRODUCTION | 1991年 / 6卷 / 07期
关键词：
COAGULATION; FIBRINOLYSIS; IVF;
D O I：
10.1093/oxfordjournals.humrep.a137461
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Effects on blood coagulation and fibrinolytic activity during ovarian stimulation for in-vitro fertilization (IVF) were examined in 12 women. Blood samples were taken prior to hormonal stimulation (days 2-3 of the menstrual cycle, mean serum oestradiol concentration 0.16 nmol/l) and the day after ovulation induction with human chorionic gonadotrophin (HCG) (days 10-12, mean serum oestradiol concentration 5.35 nmol/l). We measured whole blood clotting time, whole blood clot lysis time, plasma fibrinogen, factor VII and antithrombin III. The whole blood clotting time was slightly, but not significantly shortened after ovarian stimulation. A significant rise in plasma fibrinogen (P < 0.001) and reduction in antithrombin III (P < 0.001) were observed, whereas no change in factor VII was found. The blood fibrinolytic activity was significantly reduced as evaluated by an increase in the clot lysis time (P < 0.02). These results indicate that ovarian stimulation for IVF may create a state of hypercoagulability.
引用
收藏
页码：925 / 927
页数：3
相关论文
共 17 条
  • [11] Oian P., Omsjp I., Maltau J.M., Osterud B., Reduced thromboplastin activity in blood monocytes and reduced sensitivity to stimuli in vitro of blood monocytes from pregnant women, Br.J.Haematol, 59, pp. 133-137, (1985)
  • [12] Omsjd I., Oian P., Maltau J.M., Osterud B., Effects of two triphasic oral contraceptives containing ethinyl estradiol plus levonorgestrel or gestodene on blood coagulation and fibrinolysis, Acta Obstet.Gynecol.Scand, 68, pp. 27-30, (1989)
  • [13] Osterud B., Brox J.H., The clotting time of whole blood in plastic tubes: The influence of exercise, prostacyclin and acetylsalicylic acid, Thromb.Res, 29, pp. 425-435, (1983)
  • [14] Osterud B., Rapaport S.L., Synthesis of intrinsic factor X activator.Inhibition of the function of formed activator by antibodies to factor VIII and factor IX, Biochemistry, 9, pp. 1854-1861, (1970)
  • [15] Ross P.K., Paganini-Hill A., Mack T.M., Menopausal oestrogen therapy and protection from death from ischaemic heart disease, Lancet, I, pp. 858-860, (1981)
  • [16] Schafer A.I., The hypercoagulable states, Ann.Intern.Med, 10, pp. 814-828, (1985)
  • [17] Wright J.G., Cooper P., Astedt B., Lecander I., Wilde J.T., Preston F.E., Greaves M., Fibrinolysis during normal human pregnancy: Complex inter-relationships between plasma levels of tissue plasminogen activator and inhibitors and the euglobulin clot lysis time, Br.J.Haematol, 69, pp. 253-258, (1988)
12