THE SQUALESTATINS - POTENT INHIBITORS OF SQUALENE SYNTHASE, 3-HYDROXYMETHYL DERIVATIVES

被引：14

作者：

COX, B

HUTSON, JL

KEELING, SE

KIRK, BE

SRIKANTHA, ARP

WATSON, NS

机构：

[1] Glaxo Research and Development Ltd, Greenford

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(01)80537-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1.

引用

页码：1931 / 1936

页数：6

共 16 条

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