THE SQUALESTATINS - POTENT INHIBITORS OF SQUALENE SYNTHASE, 3-HYDROXYMETHYL DERIVATIVES

被引：14
作者：
COX, B
HUTSON, JL
KEELING, SE
KIRK, BE
SRIKANTHA, ARP
WATSON, NS
机构：
[1] Glaxo Research and Development Ltd, Greenford
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(01)80537-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1.
引用
收藏
页码：1931 / 1936
页数：6
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