S-D-LACTOYLGLUTATHIONE ACCUMULATION IN ACTIVATED HUMAN PLATELETS

被引：4
|
作者：
LEONCINI, G
BUZZI, E
APRILE, B
机构：
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1993年 / 25卷 / 11期
关键词：
D O I：
10.1016/0020-711X(93)90513-E
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. S-D-Lactoylglutathione accumulates in human platelets activated by agonists. Among the tested inducers thrombin is the most active. 2. The effect is dose and time-dependent. S-D-Lactoylglutathione, corresponding to depleted pool of reduced glutathione, can also be detected in platelets incubated with exogenous methylglyoxal. 3. A further significant increase was observed in platelets stimulated with trombin in the presence of methylglyoxal. 4. No change in glyoxalase activities upon platelet stimulation with thrombin was shown.
引用
收藏
页码：1565 / 1570
页数：6
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