SERUM OSTEOCALCIN CONCENTRATIONS IN PATIENTS WITH MULTIPLE-MYELOMA - CORRELATION WITH DISEASE STAGE AND SURVIVAL

被引：24
作者：
CARLSON, K
LJUNGHALL, S
SIMONSSON, B
SMEDMYR, B
机构：
[1] Department of Internal Medicine, University Hospital, Uppsala
来源：
JOURNAL OF INTERNAL MEDICINE | 1992年 / 231卷 / 02期
关键词：
MULTIPLE MYELOMA; OSTEOCALCIN; SURVIVAL;
D O I：
10.1111/j.1365-2796.1992.tb00514.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multiple myeloma affects bone, and enhanced bone resorption is a characteristic finding. In the present study the serum concentration of osteocalcin, serum bone gla-protein, which is a protein specific for bone turnover and reflects osteoblast activity, was analysed at diagnosis in 48 patients with multiple myeloma. At that time there was a significant relationship between disease stage (Durie-Salmon) and osteocalcin levels, lower levels being found in patients with more advanced disease. No relationship was found between osteocalcin and serum calcium levels. To date, 33 patients have died. There was a significant correlation between initial osteocalcin levels and patient survival. These findings suggest that serum osteocalcin could be a marker of prognostic significance for survival in multiple myeloma.
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页码：133 / 137
页数：5
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