NANOCRYSTALLINE EPSTEIN-BARR-VIRUS DECOYS

被引：14

作者：

KOSSOVSKY, N

GELMAN, A

SPONSLER, E

MILLETT, D

机构：

[1] Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Angeles

来源：

JOURNAL OF APPLIED BIOMATERIALS | 1991年 / 2卷 / 04期

关键词：

D O I：

10.1002/jab.770020406

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel biotechnology is introduced by way of the successful synthesis of nanocrystalline Epstein-Barr virus (EBV) decoys having specific in vivo immunogenic activity. Assembled from ultrafine surface modified tin oxide and purified DNA-free isolated EBV envelope proteins, the decoys consisted of < 150 nm units whose electrophoretic mobilities were similar to whole EBV; whose outer coats were strongly immunoreactive with murine monoclonal anti-EBV antibodies; and which elicited immunospecific neutralizing anti-EBV antibodies in the rabbit. The development of this carrier technology for vaccine preparations is suggested.

引用

页码：251 / 259

页数：9

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