THE RAS ONCOPROTEIN AND M-PHASE ACTIVITY

被引：71

作者：

DAAR, I

NEBREDA, AR

YEW, N

SASS, P

PAULES, R

SANTOS, E

WIGLER, M

VANDEWOUDE, GF

机构：

[1] NCI,FREDERIK CANC RES & DEV CTR,BASIC RES PROGRAM,ABL,FREDERICK,MD 21701

[2] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

[3] LEDERLE LAB,PEARL RIVER,NY 10965

[4] COLD SPRING HARBOR LAB,COLD SPRING HARBOR,NY 11724

来源：

SCIENCE | 1991年 / 253卷 / 5015期

关键词：

D O I：

10.1126/science.1829549

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The endogenous mos proto-oncogene product (Mos) is required for meiotic maturation In Xenopus oocytes, the ras oncogene product (Ras) can induce meiotic maturation and high levels of M-phase-promoting factor (MPF) independent of endogenous Mos, indicating that a parallel pathway to metaphase exists. In addition, Ras, like Mos and cytostatic factor, can arrest Xenopus embryonic cell cleavage in mitosis and maintain high levels of MPF. Thus, in the Xenopus oocyte and embryo systems Ras functions in the M phase of the cell cycle. The embryonic cleavage arrest assay is a rapid and sensitive test for Ras function.

引用

页码：74 / 76

页数：3

共 42 条

[1] ONCOGENIC RAS PROTEIN INDUCES MEIOTIC MATURATION OF AMPHIBIAN OOCYTES IN THE PRESENCE OF PROTEIN-SYNTHESIS INHIBITORS [J].