EFFECT OF CHRONIC ENALAPRIL TREATMENT ON ENZYMES RESPONSIBLE FOR THE CATABOLISM OF ANGIOTENSIN-I AND FORMATION OF ANGIOTENSIN-II

被引：25

作者：

DRUMMER, OH ^{[1
]}

KOURTIS, S ^{[1
]}

JOHNSON, H ^{[1
]}

机构：

[1] UNIV MELBOURNE,AUSTIN HOSP,DEPT MED,CLIN PHARMACOL & THERAPEUT UNIT,HEIDELBERG,VIC 3084,AUSTRALIA

来源：

BIOCHEMICAL PHARMACOLOGY | 1990年 / 39卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-2952(90)90058-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have investigated the effect of chronic administration of enalapril on the carboxypeptidases responsible for the formation of angiotensin II from angiotensin I and other peptidases known to recognize angiotensin I as a substrate in the rat. These studies have shown an increase in activity in rate of formation of des-Leu-angiotensin I in both kidney S2 and P2 centrifugal fractions as well as a decrease in the rate of degrActation of angiotensin I substrate. Similar increases in the formation of A(1-8) have been observed in kidney using A(1-9) as substrate. These two enzyme activities have been named carboxypeptidase K1 and K2, respectively to reflect their presence in rat kidney. These changes were acompanied by significant decreases in the activity of an amastatin-sensitive aminopeptidase and endopeptidase 24.11 in the kidney P2 fraction. These data suggest that chronic treatment with ACE inhibitors may differentially affect the activity of other enzymes capable of degrading angiotensin causing a substantial re-direction of angiotensin metabolism. © 1990.

引用

页码：513 / 518

页数：6

共 20 条

[1]

BARRETT AJ, 1981, METHOD ENZYMOL, V80, P535

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