TIAPRIDE IN LEVODOPA-INDUCED INVOLUNTARY MOVEMENTS

被引：28
|
作者：
LEES, AJ [1 ]
LANDER, CM [1 ]
STERN, GM [1 ]
机构：
[1] UNIV COLL HOSP LONDON,DEPT NEUROL,LONDON WC1E 6JJ,ENGLAND
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1979年 / 42卷 / 04期
关键词：
D O I：
10.1136/jnnp.42.4.380
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on levodopa-induced early morning and 'off-period' segmental dystonia. These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine receptors.
引用
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页码：380 / 383
页数：4
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