INHIBITION BY POLYAMINES OF LIPID PEROXIDE FORMATION IN RAT-LIVER MICROSOMES

被引：137

作者：

KITADA, M

IGARASHI, K

HIROSE, S

KITAGAWA, H

机构：

[1] Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Yayoi-cho

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91808-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Both NADPH- and ascorbic acid-dependent lipid peroxidations were inhibited by spermine, the degree of inhibition being greater with the former peroxidation. The effective concentration of spermine required for inhibition was higher when larger amounts of microsomes were used. However, the activities of NADPH-cytochrome c reductase and NADPH-peroxidase were not influenced by spermine. These results suggest that spermine inhibits lipid peroxidation by binding to phospholipids in the microsomes. © 1979.

引用

页码：388 / 394

页数：7

共 19 条

[1]

ATKINS JF, 1975, J BIOL CHEM, V250, P5688

[2]

Barber A A, 1967, Adv Gerontol Res, V2, P355

[3] EFFECT OF SPERMIDINE ON ACTIVITY OF DNA POLYMERASES [J].