LISTERICIDAL ACTIVITY OF HUMAN NEUTROPHIL CATHEPSIN-G

被引：20

作者：

ALFORD, CE ^{[1
]}

AMARAL, E ^{[1
]}

CAMPBELL, PA ^{[1
]}

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,1400 JACKSON ST,DENVER,CO 80206

来源：

JOURNAL OF GENERAL MICROBIOLOGY | 1990年 / 136卷

关键词：

D O I：

10.1099/00221287-136-6-997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We demonstrate that cathepsin G, derived from human neutrophils, exhibits potent in vitro antimicrobial activity against Listeria monocytogenes. Cathepsin G listericidal activity was by a non-enzymic mechanism and was dependent on the cationic nature of the molecule. The listericidal activity of cathepsin G occurred in a manner that was both time-dependent and concentration-dependent.

引用

页码：997 / 1000

页数：4

共 20 条

[1]

BARRETT AJ, 1981, METHOD ENZYMOL, V80, P561

[2]

CLARK J M, 1970, Infection and Immunity, V1, P607

[3]

CZUPRYNSKI CJ, 1985, J IMMUNOL, V134, P3449

[4]

CZUPRYNSKI CJ, 1984, J LEUKOCYTE BIOL, V35, P193

[5]

DONOWITZ GR, 1983, ADV HOST DEFENSE MEC, V3, P55

[6]

Elsbach P., 1988, INFLAMMATION BASIC P, P445

[7] ANTIBIOTIC PROTEINS OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].

GABAY, JE ;

SCOTT, RW ;

CAMPANELLI, D ;

GRIFFITH, J ;

WILDE, C ;

MARRA, MN ;

SEEGER, M ;

NATHAN, CF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) :5610-5614

[8] RECENT ADVANCES IN CHRONIC GRANULOMATOUS-DISEASE - DISCUSSION [J].

GALLIN, JI ;

BUESCHER, ES ;

SELIGMANN, BE ;

NATH, J ;

GAITHER, T ;

KATZ, P .

ANNALS OF INTERNAL MEDICINE, 1983, 99 (05) :657-674

[9] RELATIONSHIPS BETWEEN OXIDATIVE-METABOLISM, MACROPHAGE ACTIVATION, AND ANTILISTERIAL ACTIVITY [J].

GODFREY, RW ;

WILDER, MS .

JOURNAL OF LEUKOCYTE BIOLOGY, 1984, 36 (04) :533-543

[10]

HIRSCHJG, 1980, J EXP MED, V111, P323

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