INTERACTION OF CHLORPROMAZINE WITH DNA

被引：0

作者：

MOTOHASHI, N

KAMATA, K

MEYER, R

机构：

[1] METROPOLITAN RES LAB PUBL HLTH,SHINJUKU KU,TOKYO 169,JAPAN

[2] HERBERT LABS,SANTA ANA,CA 92715

来源：

ANTICANCER RESEARCH | 1990年 / 10卷 / 06期

关键词：

RAMAN SPECTRA; DEOXYRIBONUCLEOTIDES; DNA; INTERACTION; POTENTIAL ANTITUNNIOR CHLORPROMAZINE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mechanism of the potential anticancer agent chlorpromazine hydrochloride (CPZ) with DNA was investigated by the techniques of high - performance liquid chromatography (HPLC), viscosity and Raman spectroscopy. It has been suggested from HPLC work that DNA nucleotides (except nucleosides) from either a CPZ-DNA system or a CPZ - nucleotide system. Furthermore, the shear stress of the viscosity of the CPZ-DNA system and the CPZ - nucleotide systems were shown to be apparently the higher increasing than that of DNA and nucleotide alone. These systems had non - Newtonian properties for the formation of the CPZ - DNA and the CPZ - nucleotide systems under experimental conditions. The Raman spectra showed a dramatic difference at 982 cm-1 due to the symmetric P-O streching vibration of the PO4(2-) group between dGMP and the CPZ - dGMP system.

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页码：1611 / 1614

页数：4

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