SIMPLE AND RAPID HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PAPAVERINE IN PLASMA

被引：15
作者：
PIERSON, SL
HANIGAN, JJ
TAYLOR, RE
MCCLURG, JE
机构：
[1] Biological Division, Harris Laboratories, Inc, Lincoln, Nebraska
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 12期
关键词：
High‐pressure liquid chromatography—‐analysis; papaverine in human plasma; bioavailability; Papaverine—analysis; high‐pressure liquid chromatography; human plasma; Relaxants (smooth muscle)—papaverine; high‐pressure liquid chromatographic analysis;
D O I：
10.1002/jps.2600681224
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A rapid and sensitive high‐pressure liquid chromatographic (HPLC) assay is described for the quantification of papaverine in plasma. A paired‐ion, reversed‐phase system was employed with detection at 254 nm. This procedure yielded reproducible results with a sensitivity of 2 ng/ml. Total extraction and quantification time was < 1 hr. The suitability of this procedure for plasma sample analysis from a bioavailability study was demonstrated. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
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页码：1550 / 1551
页数：2
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