BIDIRECTIONAL STIMULATION OF ADHERENCE TO EXTRACELLULAR-MATRIX COMPONENTS BY HUMAN HEAD AND NECK SQUAMOUS CARCINOMA-CELLS AND ENDOTHELIAL-CELLS

被引：7
作者：
TAITZ, A
PETRUZZELLI, GJ
LOZANO, Y
SHANKAR, R
YOUNG, MRI
机构：
[1] EDWARD HINES JR VET ADM HOSP,RES SERV,HINES,IL 60141
[2] LOYOLA UNIV,STRITCH SCH MED,DEPT OTOLARYNGOL,MAYWOOD,IL 60153
[3] LOYOLA UNIV,STRITCH SCH MED,INST SHOCK TRAUMA,MAYWOOD,IL 60153
[4] LOYOLA UNIV,STRITCH SCH MED,DEPT PATHOL,MAYWOOD,IL 60153
来源：
CANCER LETTERS | 1995年 / 96卷 / 02期
关键词：
CANCER; METASTASIS; ANGIOGENESIS; INTEGRIN; EXTRACELLULAR MATRIX COMPONENTS;
D O I：
10.1016/0304-3835(95)03939-T
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Head and neck squamous cell carcinoma (HNSCC) cultures were established from two patients to determine if cancer and endothelial cells bi-directionally regulate their adherence to extracellular matrix components (ECM), an important process for tumor vascularization and metastasis. Soluble products from endothelial cells transiently enhanced adherence by HNSCC to ECM and increased surface levels of beta 1 and beta 4 integrins, although not beta 3. HNSCC products enhanced endothelial cell adherence to fibronectin and laminin, and beta 1 and beta 4 expression. These data show bi-directional enhancement of adherence to ECM and integrin expression among endothelial and tumor cells, which may facilitate metastasis and neovascularization.
引用
收藏
页码：253 / 260
页数：8
相关论文
共 30 条
[11]  
2-B
[12]   TRANSFORMING GROWTH-FACTOR-BETA-1 IS A NEGATIVE REGULATOR FOR DIFFERENTIATED THYROID-CANCER - STUDIES OF GROWTH, MIGRATION, INVASION, AND ADHESION OF CULTURED FOLLICULAR AND PAPILLARY THYROID-CANCER CELL-LINES [J].
HOLTING, T ;
ZIELKE, A ;
SIPERSTEIN, AE ;
CLARK, OH ;
DUH, QY .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (03) :806-813
[13]   REGULATION OF FIBRONECTIN AND LAMININ RECEPTOR EXPRESSION, FIBRONECTIN AND LAMININ SECRETION IN HUMAN COLON-CANCER CELLS BY TRANSFORMING GROWTH FACTOR-BETA(1) [J].
HUANG, S ;
CHAKRABARTY, S .
INTERNATIONAL JOURNAL OF CANCER, 1994, 57 (05) :742-746
[14]   VLA-2 MEDIATES THE INTERACTION OF COLLAGEN WITH ENDOTHELIUM DURING IN-VITRO VASCULAR TUBE FORMATION [J].
JACKSON, CJ ;
KNOP, A ;
GILES, I ;
JENKINS, K ;
SCHRIEBER, L .
CELL BIOLOGY INTERNATIONAL, 1994, 18 (09) :859-867
[15]  
JULIANO RL, 1993, SEMIN CANCER BIOL, V4, P277
[16]  
JULIANO RL, 1994, CURR OPIN CELL BIOL, V5, P812
[17]  
LEEMANS CR, 1994, CANCER-AM CANCER SOC, V73, P187, DOI 10.1002/1097-0142(19940101)73:1<187::AID-CNCR2820730132>3.0.CO
[18]  
2-J
[19]   E-CADHERIN EXPRESSION IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA IS ASSOCIATED WITH CLINICAL OUTCOME [J].
MATTIJSSEN, V ;
PETERS, HM ;
SCHALKWIJK, L ;
MANNI, JJ ;
VANTHOFGROOTENBOER, B ;
DEMULDER, PHM ;
RUITER, DJ .
INTERNATIONAL JOURNAL OF CANCER, 1993, 55 (04) :580-585
[20]  
MECHTERSHEIMER G, 1994, VIRCHOWS ARCH, V425, P375
123