BIDIRECTIONAL STIMULATION OF ADHERENCE TO EXTRACELLULAR-MATRIX COMPONENTS BY HUMAN HEAD AND NECK SQUAMOUS CARCINOMA-CELLS AND ENDOTHELIAL-CELLS

被引：7
作者：
TAITZ, A
PETRUZZELLI, GJ
LOZANO, Y
SHANKAR, R
YOUNG, MRI
机构：
[1] EDWARD HINES JR VET ADM HOSP,RES SERV,HINES,IL 60141
[2] LOYOLA UNIV,STRITCH SCH MED,DEPT OTOLARYNGOL,MAYWOOD,IL 60153
[3] LOYOLA UNIV,STRITCH SCH MED,INST SHOCK TRAUMA,MAYWOOD,IL 60153
[4] LOYOLA UNIV,STRITCH SCH MED,DEPT PATHOL,MAYWOOD,IL 60153
来源：
CANCER LETTERS | 1995年 / 96卷 / 02期
关键词：
CANCER; METASTASIS; ANGIOGENESIS; INTEGRIN; EXTRACELLULAR MATRIX COMPONENTS;
D O I：
10.1016/0304-3835(95)03939-T
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Head and neck squamous cell carcinoma (HNSCC) cultures were established from two patients to determine if cancer and endothelial cells bi-directionally regulate their adherence to extracellular matrix components (ECM), an important process for tumor vascularization and metastasis. Soluble products from endothelial cells transiently enhanced adherence by HNSCC to ECM and increased surface levels of beta 1 and beta 4 integrins, although not beta 3. HNSCC products enhanced endothelial cell adherence to fibronectin and laminin, and beta 1 and beta 4 expression. These data show bi-directional enhancement of adherence to ECM and integrin expression among endothelial and tumor cells, which may facilitate metastasis and neovascularization.
引用
收藏
页码：253 / 260
页数：8
相关论文
共 30 条
[1]   HMEC-1 - ESTABLISHMENT OF AN IMMORTALIZED HUMAN MICROVASCULAR ENDOTHELIAL-CELL LINE [J].
ADES, EW ;
CANDAL, FJ ;
SWERLICK, RA ;
GEORGE, VG ;
SUMMERS, S ;
BOSSE, DC ;
LAWLEY, TJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 99 (06) :683-690
[2]   THE RELATIONSHIP OF ANGIOGENESIS TO BIOLOGICAL-ACTIVITY IN HUMAN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK [J].
ALBO, D ;
GRANICK, MS ;
JHALA, N ;
ATKINSON, B ;
SOLOMON, MP .
ANNALS OF PLASTIC SURGERY, 1994, 32 (06) :588-594
[3]   INVITRO MODEL OF ANGIOGENESIS USING A HUMAN ENDOTHELIUM-DERIVED PERMANENT CELL-LINE - CONTRIBUTIONS OF INDUCED GENE-EXPRESSION, G-PROTEINS, AND INTEGRINS [J].
BAUER, J ;
MARGOLIS, M ;
SCHREINER, C ;
EDGELL, CJ ;
AZIZKHAN, J ;
LAZAROWSKI, E ;
JULIANO, RL .
JOURNAL OF CELLULAR PHYSIOLOGY, 1992, 153 (03) :437-449
[4]  
Bernstein Lori R., 1994, Current Opinion in Oncology, V6, P106, DOI 10.1097/00001622-199401000-00015
[5]   REQUIREMENT OF VASCULAR INTEGRIN ALPHA(V)BETA(3) FOR ANGIOGENESIS [J].
BROOKS, PC ;
CLARK, RAF ;
CHERESH, DA .
SCIENCE, 1994, 264 (5158) :569-571
[6]  
COOPER CR, 1993, INVAS METAST, V13, P178
[7]   REGULATION OF ENDOTHELIAL-CELL MORPHOGENESIS BY INTEGRINS, MECHANICAL FORCES, AND MATRIX GUIDANCE PATHWAYS [J].
DAVIS, GE ;
CAMARILLO, CW .
EXPERIMENTAL CELL RESEARCH, 1995, 216 (01) :113-123
[8]   MODULATION OF HUMAN-MELANOMA CELL METASTASIS AND ADHESION MAY INVOLVE INTEGRIN PHOSPHORYLATION MEDIATED THROUGH PROTEIN-KINASE-C [J].
DUMONT, JA ;
BITONTI, AJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 204 (01) :264-272
[9]   INTRATUMORAL MICROVESSEL DENSITY AND P53 PROTEIN - CORRELATION WITH METASTASIS IN HEAD-AND-NECK SQUAMOUS-CELL CARCINOMA [J].
GASPARINI, G ;
WEIDNER, N ;
MALUTA, S ;
POZZA, F ;
BORACCHI, P ;
MEZZETTI, M ;
TESTOLIN, A ;
BEVILACQUA, P .
INTERNATIONAL JOURNAL OF CANCER, 1993, 55 (05) :739-744
[10]  
HATHORN RW, 1994, CANCER, V74, P1904, DOI 10.1002/1097-0142(19941001)74:7<1904::AID-CNCR2820740713>3.0.CO
123