INDUCTION OF ALLOXAN STREPTOZOTOCIN DIABETES IN DOGS - A REVISED EXPERIMENTAL-TECHNIQUE

被引：37

作者：

ANDERSON, HR ^{[1
]}

STITT, AW ^{[1
]}

GARDINER, TA ^{[1
]}

LLOYD, SJ ^{[1
]}

ARCHER, DB ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST, MED RES UNIT, BELFAST BT12 6BA, NORTH IRELAND

来源：

LABORATORY ANIMALS | 1993年 / 27卷 / 03期

关键词：

DOGS; DIABETES-MELLITUS; ALLOXAN; STREPTOZOTOCIN;

D O I：

10.1258/002367793780745426

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The diabetic dog represents an excellent model for use in many aspects of diabetic research. The present paper describes, in detail, a reproducible experimental protocol for the successful induction of chemical diabetes in beagles using a combination of the 2 pancreatic beta-cell cytoxic agents alloxan and streptozotocin.

引用

页码：281 / 285

页数：5

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