MODULATION OF VOLTAGE-ACTIVATED ION CURRENTS ON IDENTIFIED NEURONS OF HELIX-POMATIA L BY INTERLEUKIN-1

被引：33

作者：

SZUCS, A

STEFANO, GB

HUGHES, TK

ROZSA, KS

机构：

[1] SUNY COLL OLD WESTBURY,OLD WESTBURY,NY 11568

[2] UNIV TEXAS,MED BRANCH,DEPT MICROBIOL,GALVESTON,TX 77550

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1992年 / 12卷 / 05期

关键词：

IMMUNOTRANSMITTER; CYTOKINE; INTERLEUKIN-1; ANTISERUM; INWARD OUTWARD CURRENTS; HELIX NEURONS;

D O I：

10.1007/BF00711543

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. The effect of interleukin-1 (IL-1) was studied on voltage-activated ion currents of the identified central neurons of Helix pomatia L. using a two-microelectrode voltage clamp. The voltage-activated inward current (I(Ca)) was decreased, whereas the outward current (I(net K)) was increased by IL-1. 2. IL-1 affects both the transient and the delayed rectifying potassium currents. The IL-1 modulatory effect on the voltage-activated ion currents was voltage and dose dependent. The threshold concentration for IL-1 was 2 U/ml. 3. The proposed modulatory effect of IL-1 appears to have more than one site of action on the neuron membrane ion channels. 4. Rabbit anti-human IL-1 polyclonal antiserum eliminated the IL-1 effects on the voltage-activated inward and outward currents. This is the first report demonstrating a direct effect of IL-1 modulation of voltage-activated ion currents on neurons of mollusks.

引用

页码：429 / 438

页数：10

共 24 条

[21] THE DYNAMICS OF CONCEPTUAL CHANGE IN 20TH-CENTURY IMMUNOLOGY [J].