LOCALIZATION OF THE FIBROBLAST GROWTH-FACTOR RECEPTOR-4 GENE TO CHROMOSOME REGION 5Q33-QTER

被引：16
作者：
ARMSTRONG, E
PARTANEN, J
CANNIZZARO, L
HUEBNER, K
ALITALO, K
机构：
[1] UNIV HELSINKI,DEPT PATHOL,CANC BIOL LAB,SF-00290 HELSINKI 29,FINLAND
[2] TEMPLE UNIV,HLTH SCI CTR,SCH MED,FELS INST CANC RES & MOLEC BIOL,PHILADELPHIA,PA 19140
来源：
GENES CHROMOSOMES & CANCER | 1992年 / 4卷 / 01期
关键词：
D O I：
10.1002/gcc.2870040116
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33-qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33-qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki-1 lymphomas.
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页码：94 / 98
页数：5
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