EFFECTS OF MIDAZOLAM ON INSULIN-SECRETION FROM ISOLATED RAT PANCREATIC-ISLETS OF LANGERHANS

被引：4

作者：

DESBOROUGH, JP ^{[1
]}

JONES, PM ^{[1
]}

PERSAUD, SJ ^{[1
]}

HOWELL, SL ^{[1
]}

机构：

[1] KINGS COLL,DIV BIOMED SCI,LONDON W8 7AH,ENGLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1993年 / 70卷 / 02期

关键词：

HORMONES; INSULIN; HYPNOTICS; BENZODIAZEPINES; MIDAZOLAM;

D O I：

10.1093/bja/70.2.221

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Isolated, cultured rat pancreatic islets of Langerhans were incubated in medium containing glucose 2 or 20 mmol litre-1 and with glucose supplemented with midazolam 10, 100 or 1000 ng ml-1. Glucose 20 mmol litre-1 with the addition of noradrenalin 10 mumol litre-1 was used as a control in contrast with noradrenaline, midazolam did not inhibit glucose-induced insulin secretion, Noradrenaline 10 mumol litre-1 inhibited secretion to basal values in response to glucose 20 mmol litre-1 (P < 0.001)

引用

页码：221 / 222

页数：2

共 6 条

[1] MIDAZOLAM MODIFIES PANCREATIC AND ANTERIOR-PITUITARY HORMONE-SECRETION DURING UPPER ABDOMINAL-SURGERY [J].