PROTECTION AGAINST CARBON-TETRACHLORIDE-INDUCED LYMPHOID ORGANOTOXICITY IN RATS BY PROTEIN-A

被引：13

作者：

SINGH, KP

ZAIDI, SIA

RAISUDDIN

SAXENA, AK

DWIVEDI, PD

SETH, PK

RAY, PK

机构：

[1] IND TOXICOL RES CTR,DIV PREVENT TOXICOL,POB 80,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] IND TOXICOL RES CTR,DIV DEV TOXICOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

TOXICOLOGY LETTERS | 1990年 / 51卷 / 03期

关键词：

Carbon tetrachloride; Lymphoid organotoxicity; Protection; Protein A;

D O I：

10.1016/0378-4274(90)90077-Y

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

In a previous study we described protection of rats from carbon tetrachloride (CCl4)-induced hepatotoxicity by protein A (PA). In the present report we described protection against CCl4-induced lymphoid organotoxicity in rats by PA. Our data indicate that CCl4 administration produced a significant increase in the number of total leukocytes and polymorphs in blood, a significant decrease in leukocyte count in bone marrow, and a significant loss in weight of spleen and adrenals. In the animals receiving PA prior to and after CCl4, these values were found to be near those of controls. Histological examination revealed thymocyte depletion in thymic lobe and degenerative changes of tissue in spleen of CCl4-exposed animals. PA treatment to CCl4-exposed animals exhibited improvement and recovery from the damage caused by CCl4. These observations throw a new light on the field of ccl4 toxicity to lymphoid organs and their protection by PA. © 1990.

引用

页码：339 / 351

页数：13

共 34 条

[1] ORAL TOXICITY OF CARBON-TETRACHLORIDE - ACUTE, SUBACUTE, AND SUBCHRONIC STUDIES IN RATS [J].