Hepatotoxicity Secondary to Chemotherapy

被引：127
作者：
Grigorian, Alla [1 ,2 ]
O'Brien, Christopher B.
机构：
[1] Univ Miami, Sch Med, Div Liver Transplantat, 1500 NW 12th Ave,Suite 1101, Miami, FL 33136 USA
[2] Univ Miami, Sch Med, Div GI Transplantat, 1500 NW 12th Ave,Suite 1101, Miami, FL 33136 USA
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2014年 / 2卷 / 02期
关键词：
Hepatotoxicity; Drugs; Cancer; Chemotherapy; Liver;
D O I：
10.14218/JCTH.2014.00011
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The difficult problem faced by multiple generation of practicing physicians is determining the cause of abnormal liver function tests in cancer patients on chemotherapy. Hepatotoxicity from chemotherapy occurs frequently from an unpredictable or idiosyncratic reaction. Despite remarkable advances in our understanding of the mechanisms of action, pharmacodynamics, and interrelationships between the liver and chemotherapy, the underlying etiology of hepatic toxicity for various agents remains unexplained. Here, we present a concise review of the broad differential diagnosis for abnormal liver function tests (LFTs) in oncology patients. (C) 2014 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved.
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页码：95 / 102
页数：8
相关论文
共 91 条
[1]  
AMROMIN GD, 1962, GASTROENTEROLOGY, V42, P401
[2]   ETOPOSIDE PHARMACOKINETICS IN PATIENTS WITH NORMAL AND ABNORMAL ORGAN FUNCTION [J].
ARBUCK, SG ;
DOUGLASS, HO ;
CROM, WR ;
GOODWIN, P ;
SILK, Y ;
COOPER, C ;
EVANS, WE .
JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (11) :1690-1695
[3]   SCLEROSING HEPATITIS AND AZATHIOPRINE [J].
BARROWMAN, JA ;
KUTTY, PK ;
RA, MU ;
HUANG, SN .
DIGESTIVE DISEASES AND SCIENCES, 1986, 31 (02) :221-222
[4]  
BATEMAN JR, 1971, CANCER-AM CANCER SOC, V28, P907, DOI 10.1002/1097-0142(1971)28:4<907::AID-CNCR2820280414>3.0.CO
[5]  
2-9
[6]  
BENJAMIN RS, 1974, CANCER, V33, P19, DOI 10.1002/1097-0142(197401)33:1<19::AID-CNCR2820330107>3.0.CO
[7]  
2-M
[8]   10-YEARS EXPERIENCE WITH METHOTREXATE AND FOLINIC ACID AS PRIMARY THERAPY FOR GESTATIONAL TROPHOBLASTIC DISEASE [J].
BERKOWITZ, RS ;
GOLDSTEIN, DP ;
BERNSTEIN, MR .
GYNECOLOGIC ONCOLOGY, 1986, 23 (01) :111-118
[9]  
Bisogno G, 1997, MED PEDIATR ONCOL, V29, P245, DOI 10.1002/(SICI)1096-911X(199710)29:4<245::AID-MPO2>3.3.CO
[10]  
2-X
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