Refractory IgG Warm Autoimmune Hemolytic Anemia Treated with Eculizumab: A Novel Application of Anticomplement Therapy

被引：15

作者：

Ma, Kim ^{[1
]}

Caplan, Stephen ^{[1
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Div Hematol, Dept Med, 3755 Chemin Cote St Catherine,Room E-72, Montreal, PQ H3T 1E2, Canada

来源：

CASE REPORTS IN HEMATOLOGY | 2016年 / 2016卷

关键词：

D O I：

10.1155/2016/9181698

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Warm autoimmune hemolytic anemia (wAIHA) is the most common form of AIHA, with corticosteroids in first-line treatment resulting in a 60-80% response rate. Atypical wAIHA and IgG plus complement mediated disease have a higher treatment failure rate and higher recurrence rate. We report a case of severe wAIHA secondary to Waldenstrom macroglobulinemia with life threatening intravascular hemolysis refractory to prednisone, rituximab, splenectomy, and plasmapheresis. A four-week treatment of eculizumab in this heavily pretreated patient resulted in a sustained increase in hemoglobin and transfusion independence, suggesting a role for complement inhibition in refractory wAIHA.

引用

页数：3

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