CONCENTRATION-DEPENDENT EFFECT OF IRON ON GAMMA-LINOLENIC ACID TOXICITY IN ZR-75-1 HUMAN BREAST-TUMOR CELLS IN CULTURE

被引：14

作者：

CANTRILL, RC

ELLS, G

CHISHOLM, K

HORROBIN, DF

机构：

[1] Efamol Research Institute, Kentville, NS

来源：

CANCER LETTERS | 1993年 / 72卷 / 1-2期

关键词：

IRON; POLYUNSATURATED FATTY ACID; CYTOTOXICITY; HUMAN BREAST TUMOR CELLS; TISSUE CULTURE;

D O I：

10.1016/0304-3835(93)90017-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polyunsaturated fatty acids are cytotoxic to ZR-75-1 human breast tumor cells in culture. This effect may be potentiated by the simultaneous addition of iron. When cytotoxicity was measured in the presence of different concentrations of both gamma-linolenic acid and ferrous chloride there was an increase in cell death above concentrations of 9 muM and 0.05 muM, respectively. The potentiation of the effects of 18:3n-6 at low concentrations by the simultaneous addition of Fe(II) ions supports the contention that an alteration in the intracellular Fe(II)/Fe(III) ratio is necessary to promote autocatalytic lipid peroxidation.

引用

页码：99 / 102

页数：4

共 18 条

[1]

AUST SD, 1982, FREE RAD BIOL, V5, P29

[2]

BEGIN ME, 1986, JNCI-J NATL CANCER I, V77, P1053

[3] POLY-UNSATURATED FATTY ACID-INDUCED CYTO-TOXICITY AGAINST TUMOR-CELLS AND ITS RELATIONSHIP TO LIPID-PEROXIDATION [J].