MALARIA TRANSMISSION-BLOCKING ACTIVITY IN EXPERIMENTAL INFECTIONS OF ANOPHELES-GAMBIAE FROM NATURALLY INFECTED PLASMODIUM-FALCIPARUM GAMETOCYTE CARRIERS

被引：45
作者：
MULDER, B
TCHUINKAM, T
DECHERING, K
VERHAVE, JP
CARNEVALE, P
MEUWISSEN, JHET
ROBERT, V
机构：
[1] UNIV NIJMEGEN, DEPT MED PARASITOL, 6500 HB NIJMEGEN, NETHERLANDS
[2] ORSTOM, OCEAC, MED ENTOMOL SERV, YAOUNDE, CAMEROON
[3] UNIV YAOUNDE, FAC SCI, YAOUNDE, CAMEROON
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 88卷 / 01期
关键词：
D O I：
10.1016/0035-9203(94)90534-7
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Experimental infections of anopheline mosquitoes were carried out with Plasmodium falciparum gametocytes from 65 naturally infected patients in Cameroon. A comparison was made between infections with blood containing autologous plasma and blood in which the plasma was replaced with plasma from a donor without previous malaria exposure. A lower infection rate was observed in 50 of 65 autologous plasma samples. Transmission was significantly blocked in 3 infections. This indicates that, in a population living in an area endemic for malaria, blood plasma factor(s) can reduce the transmission capacity of gametocyte carriers to mosquitoes.
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页码：121 / 125
页数：5
相关论文
共 38 条
  • [1] RECOMBINANT PFS25 PROTEIN OF PLASMODIUM-FALCIPARUM ELICITS MALARIA TRANSMISSION-BLOCKING IMMUNITY IN EXPERIMENTAL-ANIMALS
    BARR, PJ
    GREEN, KM
    GIBSON, HL
    BATHURST, IC
    QUAKYI, IA
    KASLOW, DC
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (05) : 1203 - 1208
  • [2] BOYD MF, 1949, MALARIOLOGY, V1, P551
  • [3] MALARIA TRANSMISSION BLOCKED BY IMMUNIZATION WITH GAMETES OF MALARIA PARASITE
    CARTER, R
    CHEN, DH
    [J]. NATURE, 1976, 263 (5572) : 57 - 60
  • [4] CARTER R, 1988, PROG ALLERGY, V41, P193
  • [5] PLASMODIUM-FALCIPARUM - EFFECT OF CHLOROQUINE, HALOFANTRINE AND PYRIMETHAMINE ON THE INFECTIVITY OF GAMETOCYTES FOR ANOPHELES-STEPHENSI MOSQUITOS
    CHUTMONGKONKUL, M
    MAIER, WA
    SEITZ, HM
    [J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1992, 86 (02): : 103 - 110
  • [6] COVELL G, 1955, CHEMOTHERAPY MALARIA, P89
  • [7] PFS2400 CAN MEDIATE ANTIBODY-DEPENDENT MALARIA TRANSMISSION INHIBITION AND MAY BE THE PLASMODIUM-FALCIPARUM 11.1 GENE-PRODUCT
    FENG, Z
    HOFFMANN, RN
    NUSSENZWEIG, RS
    TSUJI, M
    FUJIOKA, H
    AIKAWA, M
    LENSEN, THW
    PONNUDURAI, T
    POLOGE, LG
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) : 273 - 281
  • [8] TRANSMISSION BLOCKING IMMUNITY TO HUMAN PLASMODIUM-VIVAX MALARIA IN AN ENDEMIC POPULATION IN KATARAGAMA, SRI-LANKA
    GAMAGEMENDIS, AC
    RAJAKARUNA, J
    CARTER, R
    MENDIS, KN
    [J]. PARASITE IMMUNOLOGY, 1992, 14 (04) : 385 - 396
  • [9] THE RESERVOIR OF PLASMODIUM-FALCIPARUM MALARIA IN A HOLOENDEMIC AREA OF WESTERN KENYA
    GITHEKO, AK
    BRANDLINGBENNETT, AD
    BEIER, M
    ATIELI, F
    OWAGA, M
    COLLINS, FH
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1992, 86 (04) : 355 - 358
  • [10] MEASUREMENT OF MALARIAL INFECTIVITY OF HUMAN-POPULATIONS TO MOSQUITOS IN THE MADANG AREA, PAPUA-NEW-GUINEA
    GRAVES, PM
    BURKOT, TR
    CARTER, R
    CATTANI, JA
    LAGOG, M
    PARKER, J
    BRABIN, BJ
    GIBSON, FD
    BRADLEY, DJ
    ALPERS, MP
    [J]. PARASITOLOGY, 1988, 96 : 251 - 263
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