ORGANIZING ACTIVITY OF WINGLESS PROTEIN IN DROSOPHILA

被引：738
作者：
STRUHL, G
BASLER, K
机构：
[1] Howard Hughes Medical Institute Columbia University College of Physicians and Surgeons New York
来源：
CELL | 1993年 / 72卷 / 04期
关键词：
D O I：
10.1016/0092-8674(93)90072-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The adult appendages of Drosophila are formed from imaginal discs, sheets of epithelial cells that proliferate during larval development and differentiate during metamorphosis. wingless (wg, DWnt-1) protein, a putative signaling molecule, is expressed only in prospective ventral cells in each of the leg discs. To test the role of wg, we have generated randomly positioned clones of cells that express wg protein constitutively. Clones that arise in the prospective ventral portions of the leg discs develop normally. In contrast, dorsally situated clones give rise to ventrolateral patterns and exert a ventralizing influence on neighboring wild-type tissue. We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc.
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收藏
页码：527 / 540
页数：14
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