Global change instruction for undergraduate college students should emphasize relationships among the natural sciences, social sciences, and humanities over specialized study of each. Potentially any of these areas of knowledge could be the starting point for multidisciplinary understanding of a changing global environment. A groundwork has been laid at Florida State University, based on experience in teaching honors students from a natural science and especially chemistry perspective, for a broader teaching program for general freshman and sophomore students who intend to major in any area.